The first time I watched Up, I wasn't infertile yet, or at least I didn't know I was infertile. The ex and I had only been trying for about 4 months, and I still thought it would happen at any time. So at that point, the infertility in the storyline didn't affect me any more than any other part. Still, a friend that saw the movie with me and I came out of seeing it with the reaction of, "that is SO NOT a kid's movie!!" Even without being infertile, the beginning of the movie basically says, "Hey, kids, you're never going to reach your life's dreams, even if you try to save up for them, because no matter how hard you try, life is going to kick you in the ass and take everything from you, and if you finally manage to reach that dream, you'll either be the one to die when it's about to happen or the one left alone to watch what you have left destroyed. But hey, there's a talking dog!" (Bear adds, "Oh, yeah, and if you're a Scout, you should harass the old grumpy people when you go door to door.")
I tried to watch it again tonight, since there wasn't anything else good on and I wanted to record it for the kids. When they do finally watch the recording, I'll be somewhere else when the beginning plays, because I don't ever want to see that beginning again.
On the other hand, I love Bear for asking if I wanted to turn the movie off (which I did after the funeral scene) and for holding my hand while I was watching it and for offering to put it on for the kids sometime when I'm not home.